the first paper show that for one functional protein we will need more then 10^70 mutations:
evolutionists claim that this protein may evolve from a simpler one. but here is another paper that show that we need most of the protein sequence for its minimal function:
so there is a minimal sequence that the protein need for a minimal function.
now, lets say that there is another functional proteins in the sequence space. lets say even 10^30 (something like milion times the number of sand grains on the earth). its still mean that we will need 10^40 mutations for a minimal function. and most of the biological systems need several proteins and not just one. a big problem for evolution.