Well, Dr. Wood flat out says that the evidence in God’s creation can be construed as pointing to evolution and an ancient earth. So, since evolution and an old earth explain the data well, he submits that solid model-building will be at the core of “the quest.” Wood argues that creationists will need a very strong model (otherwise, people will never abandon the old evolutionary one).
Anyhow (to actually address your question ), in chapter 8 of the book, Dr. Wood goes through the “hardest questions” in different scientific fields. Specifically, he wonders how we can see distant starlight, he wonders why there are patterns in radiometric dating, he wonders why living things share similarity, and he also shares some of his his thoughts on anthropology. Once again, though, the book is an optimistic one. These questions are not simply idle wondering or insurmountable obstacles. They are hard problems waiting to be solved!
@Jammycakes, I seriously think you should check the book out! Todd Wood has a refreshing perspective, and I would be very curious to hear what you think of it! (An added benefit of reading the book would be that you would not have to rely on my personal analysis of it ).
@aarceng, I would be delighted to hear your thoughts as well!
(P.S: I would gladly hear the thoughts of @EvolvingLutheran, @mlkluther, and other Biologos friends as well. )