Most Beneficial Mutations

What do you consider the most beneficial mutations in humans in the last 20,000 years or so?

Lactose tolerance comes to mind as one that is widespread, especially among Europeans.

Another rare one is:

https://www.washingtonpost.com/archive/politics/1994/10/18/mutation-among-italians-appears-to-protect-heart/02d47414-edcb-4c24-855a-757fcc8ca515/

What do you think?

“Let your conversation be always full of grace, seasoned with salt, so that you may know how to answer everyone.” -Colossians 4:6

This is a place for gracious dialogue about science and faith. Please read our FAQ/Guidelines before posting.