Most Beneficial Mutations

What do you consider the most beneficial mutations in humans in the last 20,000 years or so?

Lactose tolerance comes to mind as one that is widespread, especially among Europeans.

Another rare one is:

https://www.washingtonpost.com/archive/politics/1994/10/18/mutation-among-italians-appears-to-protect-heart/02d47414-edcb-4c24-855a-757fcc8ca515/

What do you think?