First thing that came to my mind…also by Michelangelo. I’ve been fortunate enough to see the original, in the Uffizi in Florence (saw the David & the Pieta in Florence, as well). The painting is notable for a couple things. First, it’s unusual for being originally painted on a round canvas, and it still exists in its original framing this way. Second, it’s one of the first paintings to go beyond just the standard medieval depiction of the Madonna & child, and to include Joseph in the Holy Family. For hundreds of years every medieval painter & his brother painted the Madonna & child w/ Baby Jesus sitting on Mary’s left knee, with Joseph nowhere to be seen. To me this captures Michelangelo’s genius, really visualizing his subject in a novel way, including having Baby Jesus coming over Mary’s right shoulder. The figure to the right is widely held to be a young John the Baptist. As for the nekkid guys in the background…the jury’s been out on them for 500 years or so.