I think an angle one can always take is, “what if you’re wrong?”
What if Covid19 is real and deadly, and failing to wear a mask or practice social distance dramatically increases the chance of catching it and spreading it? What if I catch it and spread it to 20 people before I realize I have it? What if 1 or more of those people die?
I can’t imagine God would want me to risk that happening without some very good reason. What reason could that be?
This is how I seek to discuss such things with people who are anti-science or anti-liberal or whatever. And I try to find out, before engaging in the discussion, how to approach them, so that it doesn’t come across as though I’m giving them the 3rd degree, but rather as though I’m seriously considering how to respond to the situation, which I am.