Brief summary of ERV evidence for common descent

Hello everyone - I am trying to put a brief summary of how ERVs in great apes support common descent to a skeptic that has some medical knowledge.

  1. Is the summary below a good start?
  2. Can anyone else point me to an article, YouTube video or other concise way of presenting this to a skeptic who is trained in medicine?
  3. This is the only article I have found but the skeptic is still questions if RV insertion loci are actually random.

Assumptions:

  1. It is highly unlikely (approximately 1 in 50,000,000) that an RV insertion will occur at a given loci in the human genome.
  2. RV converting into ERV is rare but does occur.
  3. Some ERVs will eventually propagate to an entire species over a long period of time.
  4. Points 1-3 are observable and repeatable, highly peer reviewed and well established with numerous experiments on bacteria, and other species over decades of time. These items are well established and not controversial for scientists in genetic research
  5. We observer not less than 16 of the same ERVs inserted into the genome at the same loci for humans, chimpanzees and other primates.
    Conclusion:
    Given 1-5 -> ERVs evidence provides strong support of common descent.

Here is the analogy I use to explain the evidence. Take two people and lock each person in a separate room with an OED dictionary. Give them instructions to randomly pick 100 entries from the dictionary and write them down. When they are done, compare the lists of words. What are the chances that any of those 100 words will match? Pretty low, right? The same applies to retroviruses when they choose a base in the genome to insert into. Therefore, when you see hundreds of thousands of retroviral insertions that are found at the same place in two different genomes you know that they had to be inherited from a common ancestor because there is no plausible way that many independent retroviral insertions will happen at the same base.

I would describe how retroviral insertions that happen in egg or sperm can be passed on to offspring who also pass the insertion along to all of their descendants. You might also add that the reason you and your siblings/cousins/relatives share the same ERV’s at the same location in each of your genomes is because you share a common ancestor.

It’s way, way more than 16. Using the human genome paper from 2001 and the chimp genome paper from 2005.


Table 11, 2001 human genome paper
Between ERV class I, II, and III, there are 203,000 ERV’s in the human genome.

Next:
image
Table 2, 2005 chimp genome paper
They only list the species specific ERV’s which would be the ERV’s not found in the other species. Therefore, of the 203,000 ERV’s found in the human genome there are only 82 that are not found in the chimp genome at the same position. This means chimps also have about 203,000 ERV’s, and of those there are only 279 not found in the human genome. Nearly all 203,000 ERV’s in each species are shared between them. This is smoking gun evidence for common ancestry.

Wow. Thanks for the answer. Learning a lot about ERVs.

Is this simple logic true?

  1. Retroviruses insert themselves into DNA in random places. (random is very key!)
  2. Sometimes the virus insertion occurs in sperm or eggs.
  3. When #2 happens, all descendants get that retrovirus and it becomes “Endogenous” or an ERV.
  4. There are roughly 200,000 virus insertions in the human DNA.
  5. There are roughly 200,000 virus insertions in chimpanzee DNA.
  6. Almost all of the 200,000 virus insertions in chimps are the same virus and the same location in the DNA as humans!
  7. ERVs will randomly mutate over time.
  8. The ERVs that are shared between chimps and humans at the same location in the DNA also share the same random mutations!

Are there any specific data or studies to support “randomness” that someone can point me to?

Good resource:

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Those last two points can be a bit confusing. The following paper has a better description of how the sequences within ERVs can be used to evidence common ancestry and evolution:

The differences in the shared ERV sequences can also evidence evolution.

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Very much appreciate the information. This is very interesting indeed!

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