In Darwin Devolves, Michael Behe argues that mutations result in only in damage and degradation of genes, which he terms “devolution.” Meaningful innovation requires something else, according to Behe.
Yet, a single point mutation in the ancient gene ARHGAP11A may have been enough to cause the neocortex of the human brain to start expanding
Primates possess only the ancient gene, while humans possess ARHGAP11B, which substitutes a C for a G at a single point, thereby triggering the production of a larger neocortex. Interestingly, a 2015 article on the subject says Neanderthal and Denisovan possess both genes (paralogs). How did that happen?
In short, Behe’s thesis is disproved by existence of ARHGAP11B, a “beneficial” mutation caused by a single substitution.
Have I misunderstood the evidence, @DennisVenema?