In Darwin Devolves, Michael Behe argues that mutations result in only in damage and degradation of genes, which he terms “devolution.” Meaningful innovation requires something else, according to Behe.
Yet, a single point mutation in the ancient gene ARHGAP11A may have been enough to cause the neocortex of the human brain to start expanding
https://www.mpi-cbg.de/news-events/latest-news/article/news/evolutionary-key-for-a-bigger-brain/
Primates possess only the ancient gene, while humans possess ARHGAP11B, which substitutes a C for a G at a single point, thereby triggering the production of a larger neocortex. Interestingly, a 2015 article on the subject says Neanderthal and Denisovan possess both genes (paralogs). How did that happen?
In short, Behe’s thesis is disproved by existence of ARHGAP11B, a “beneficial” mutation caused by a single substitution.
Have I misunderstood the evidence, @DennisVenema?