What Would Scientific Evidence for Guidance in Evolution Look Like?

If guidance is defined as a deviation from randomness then natural selection could be described as guiding beneficial mutations towards fixation.

I’m not sure what you are trying to ask.

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An alteration of the system from outside is not scientific evidence. Sounds to me like you are making God into a liar just like the creationists – having God alter the scientific evidence to say whatever He wants us to believe.

Right… with something outside the universe altering the evidence to lie saying whatever it wants… that wouldn’t be more like demons than aliens.

I do not think so. We can only theoretically detect physical interactions. Science dictates only probability distributions not individual results within those probability distributions. So as long as the probability distributions are obeyed, there is nothing to detect if the cause is non-physical.