I am sure that the virus in itself causes oxidative stress but this extreme oxidative stress is the result of the virus interfering with the RAS system as subsequent down regulation of the Ace 2 molecule which is involved in converting the Angiotensin II to Angiotensin 1-7. This downregulation leads directly to endothelial cell damage oxidative stress and evntually the release of vwf which is elevated leading to clotting. This rAS System as I am sure you know is well understood and I will send more info on that viral pathway disruption if you like,. We know that elderly populations and these risk populations with high bmi and diabetes as well as vascular disease have elevated oxidative stress and likely lower oxidative stress capacity to fend off this oxidative storm. I unspderstand what you are saying about the innate immune system but the oxidative stress capacity explains why some are so susceptible to severe symptoms while others are not. This is one of the main indicators of severe susceptibility to this virus and likely a point of intervention to significantly improve outcomes.
The one paper showed a case study of immediate benefit with iv Glutathione and there other doctors now treating with Gluathione or nac.