A professional what? Professional dog-breeder? I can tell you that most of them are only interested in breeding ‘purebreds’ whose last eight generations are all of the same breed. They are not breeding for the maintenance of compatibility with other breeds, except inasmuch as they generally want to maintain the ability to breed, period. But then any creature, wild or domestic, that doesn’t reproduce isn’t going to have much future.
You’re barking up the wrong tree with this!