Can macro evolution be replicated in a lab?

[Paraleptopecten (Timothy Campbell)]

Current changes in polyploidy of Campeloma, and sinistrality

@Paraleptopecten

The main point is that sinistral individuals can only mate with other sinistral individuals. Hence, as soon as a population appears, it could be considered a separate species (assuming that sinistrality is rare). Eventually, they may diverge noticeably from their dextral counterparts.

are two examples in mollusks of very short-term speciation.