Hi Eddie,
Bayesian analysis can move in either direction in time. If I know that a new allele confers resistance to streptomycin, for example, I can predict that it will provide greater fitness to a bacteria population in my body when I’m taking antibiotics. If a new allele reduces the leg-to-body ratio in male humans, I can predict that it will provide greater fitness to the lucky Valentinos who have it.
That said, any predictions would be probabilistic rather than binary. The overall fitness of a trait in a population in a particular environment is highly complex. And as our friend Steve stated earlier,