Great post. Fantastic. From near the end:
A new protein region, de novo, carrying with it significant new functional information—that arose through readily accessible mutational steps. While we do not yet know the precise shape of this new, composite protein, we know that it is stably folded, given that it is functional. - See more at: http://biologos.org/blogs/dennis-venema-letters-to-the-duchess/biological-information-and-intelligent-design-evolving-new-protein-folds#sthash.L9WJ2Jjy.dpuf
We do know that the new protein region is functional but I don’t think we know that it is stably folded. If I am not mistaken, there are lots of protein regions known to be – this is such a great phrase – intrinsically disordered. And this characteristic is known to be important for the function of many of those regions. In fact there are numerous tools devoted to predicting whether a domain is intrinsically disordered. IMO, unless the new region of Arhgap11b is known to be folded, we needn’t and shouldn’t say that it is. We certainly should not assume that because it has function, it is folded.