Swamidass
January 21, 2018, 11:06am
440
And, more importantly, this improvement of the estimate…
Correctly Weighting Coalescents. An improve esitmate of TMRCA is about 500 kya.
At the moment, all coalescents are weighted equally. This biases the averages to high recombination areas, which might be biased towards upward errors in TMRCA estimates. It would be wiser to average weighting by the length of the DNA segment to which the phylogeny applies.
I finally got around to correcting this part of the code, and recomputing the TMR4A. Here is what we arrive at, a TMR4A of 495 kya, nearly 500 kya. This is a better estimate.
https://discourse-cdn-sjc2.com/standard9/uploads/peacefulscience/original/1X/94c9420257f170b3e5f847aff3363ba3451568a2.png
1 Like