What I’m talking about there is a summary of the field as a whole - and the PSMC analyses in the 1,000 genomes paper is certainly one of the relevant experiments. So are LD studies. So are the Li and Durban PSMC results. All are based on examining present-day alleles in present-day populations (of course - it couldn’t be otherwise unless we’re talking paleogenomics). Some of these analyses use a forward mutation rate (which is also the rate of fixation for neutral alleles, and most variation is neutral). I know you think PMSC studies could miss a bottleneck to two. I disagree, but you’re going to have to wait until I have time to write it up and explain why I think you’re mistaken. Part II might include PSMC, or it might not. Part of my goal here is to not just explain my reasoning to you as a biologist, but to make it accessible to a non-specialist audience. That takes more time.
1 Like