Let’s say that there are basic physical constants that are variable through space and time. What we find is that we get very different results from the Fermi accelerator in Texas and the CERN accelerator in France, even under identical conditions. We also observe that the results change through time at both locations. Scientists are not able to make predictions and test them at either location. Science doesn’t work.
I understand - I guess I was anticipating a more detailed and perhaps challenging argument from you on what we understand as laws of nature. In any event it is always stimulating intellectually to argue from opposing positions.