COVID-19 Immune response and vaccine

[03Cobra (Vance)]

Chris,
I would prefer not to make this discussion about me. I think ideas are a better topic of discussion.

As far as loving your neighbor as yourself, a command that I fully embrace, there are different ways to view what that love looks like in action.

For example, some are adamant that that requires mask wearing. Others feel strongly that love for our neighbors is shown by, among other things, helping to protect the freedoms of individuals.

[Chris_Falter]

@03Cobra

I would prefer not to make this discussion about me.

You already made the discussion in part about you when you said that you don’t doubt the expertise of Birx and Fauci.

The horse is out of the barn and you need to deal with it.

If you choose not to, you leave yourself open to the inference that your profession of respect for Birx and Fauci only goes as far as they help you win debating points, and stops where they ask you to behave in a manner that protects your neighbors from health hazards that you may inadvertently pose.

@03Cobra

Others feel strongly that love for our neighbors is shown by, among other things, helping to protect the freedoms of individuals.

You can do both simultaneously: you can wear a mask even while you lobby for the right of others not to wear a mask, just as it is possible for you to evangelize Muslims even as you lobby for the Constitutional right of a Muslims to build mosques and worship in the Islamic tradition.

Best,
Chris

[03Cobra (Vance)]

I gave my opinion on Dr. Birx and Dr. Fauci in response to a comment that they should not be listened to.

That is not making the discussion about me. I certainly can’t keep people from making inferences that I did not imply.

What do you think of the topic of the thread?

[T_aquaticus]

From the article in the OP:

Among the main findings was that IgG levels in 93% (28/30) of the asymptomatic group and 97% (30/31) of the symptomatic group declined greatly during the early convalescent phase (by 8 weeks after release from the hospital). Antibody levels dropped by 71.1% in asymptomatic patients and 76.2% in the symptomatic group.

This appears to be similar to what is seen with the flu virus. One study I found shows a 75% decrease in antibody titer 11-12 months after immunization among healthy individuals.

Lack of persistence of influenza vaccine antibody titers in patients with...

An annual or bi-annual SARS shot might be needed, just like annual flu shots.

[T_aquaticus]

Another interesting paper on influenza A,

Six months and one year after antibodies peaked following presumptive infection with A(H1N1)pdm09, only 25% and 14% of participants respectively had antibody titers against A(H1N1)pdm09 that would be considered protective (HI titer ≥ 40). The decline in antibody titers may explain susceptibility to re-infections, and recurrent epidemics following the initial epidemic of infections during the pandemic. It also suggests that influenza vaccination may have to be administered more frequently in the tropics where there is year-round circulation of influenza viruses. The rate of decline in elderly individuals may be even more rapid, and if our findings are confirmed, may necessitate alternative strategies of influenza vaccine development for this vulnerable group.
Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore - PMC

Influenza A might serve as a useful analog for what we can expect from SARS-COV2. The flu does spring back up on smaller scales in previously infected populations, and reductions in titers is one explanation being put forward.

This should also serve as encouragement to our elder populations to get their annual flu shots. Not only are they more susceptible to the flu, but they also have a sharper decrease in antibody titers.

[Chris_Falter]

@03Cobra

What do you think of the topic of the thread?

I am not qualified to speak to the topic. It seems that we might need to have regular SARS shots, as @T_aquaticus noted.

Best,
Chris